High-Dose Folic Acid Pretreatment Blunts Cardiac Dysfunction During Ischemia Coupled to Maintenance of High-Energy Phosphates and Reduces Postreperfusion Injury
نویسندگان
چکیده
An L. Moens, MD; Hunter C. Champion, MD, PhD; Marc J. Claeys, MD, PhD; Barbara Tavazzi, MD, PhD; Pawel M. Kaminski, MD, PhD; Michael S. Wolin, MD, PhD; Dirk J. Borgonjon, MS; Luc Van Nassauw, PhD; Azeb Haile, MS; Muz Zviman, PhD; Djahida Bedja, MS; Floris L. Wuyts, PhD; Rebecca S. Elsaesser, PhD; Paul Cos, PhD; Kathy L. Gabrielson, DVM, PhD; Giuseppe Lazzarino, MD, PhD; Nazareno Paolocci, MD, PhD; Jean-Pierre Timmermans, PhD; Christiaan J. Vrints, MD, PhD; David A. Kass, MD
منابع مشابه
Letter by Greyson regarding article, "High-dose folic acid pretreatment blunts cardiac dysfunction during ischemia coupled to maintenance of high-energy phosphates and reduces postreperfusion injury".
BACKGROUND The B vitamin folic acid (FA) is important to mitochondrial protein and nucleic acid synthesis, is an antioxidant, and enhances nitric oxide synthase activity. Here, we tested whether FA reduces myocardial ischemic dysfunction and postreperfusion injury. METHODS AND RESULTS Wistar rats were pretreated with either FA (10 mg/d) or placebo for 1 week and then underwent in vivo transie...
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Background and Objective: Cardiac ischemia-reperfusion (IR) is one of the main causes of death in the world. Since exercise training is one of the practical ways to improve cardioprotection against these injuries, the purpose of the present study was to investigate the effect of preconditioning with a short term of high-intensity interval training on cardioprotection, left ventricular function ...
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تاریخ انتشار 2008